Each year, about 9.9 American adults deal with it. That is roughly five percent of the overall adult population,
give or take a few. Extreme depression is unlike the normal feelings of sadness, loss, or passing mood states
that many people have.

The condition is more persistent, and because of that persistence, it might significantly disrupt your thoughts,
habits, mood, activity, and even physical health. According to the World Health Organization (WHO), extreme
depression is set to become the second leading cause of disability in the world, after heart disease. The onset
of severe depression might be gradual, so the symptoms are not obvious right away.

Nonetheless, a few of the indications to keep an eye out for to identify whether you are suffering from severe
depression or not consist of the following: persistently sad state of mind or high irritability,
marked shifts in regular routines, consisting of sleep and appetite. Noticable changes in energy such as
frequently low energy practically daily. Feelings of being slowed down or agitation such as loss of interest in
previously pleasant activities. Relentless sensations of shame, unimportance, hopelessness, and emptiness may
also occur.

Other symptoms that are brought on by depression are reoccurring ideas of death or suicide, consistent physical
signs like headaches, intestinal disorders, and persistent pain without any known cause, and do not respond to
therapy. If you experience a number of of these symptoms of major depression, and they happen at the same time
for approximately longer than two weeks, and in such a way that they interfere with normal functioning, then do
not think twice to ask for expert treatment.

The reasons for severe depression are different, and the events that led to the development of the condition,
are in some cases too numerous to determine a single one as the clear-cut cause. There are typically lots of
aspects involved such as physical, biological, and even environmental aspects that all play a role.

According to scientific research, however, extreme depression is mainly a brain disorder. The problem could be
traced back to three chemicals or neurotransmitters, which function as messengers that transfer electric signals
between brain cells. These are norepinephrine, serotonin, and dopamine.

A person suffering from major depression often exhibits a chemical imbalance between these three
neurotransmitters, thus, producing a clinical state where depression takes place. In order to make up for the
imbalance, antidepressant drugs are introduced. These drugs work by increasing the availability of
neurotransmitters, or by changing the level of sensitivity of the receptors for these chemical messengers.

It is not enough however, to deal with major depression with psychotherapeutic drugs alone. Some individuals may
respond better to cognitive therapy, wherein they are given assistance in managing the problem areas of their
lives that add to depression. Additionally, individuals with severe depression may react to treatment
incorporating both approaches of medication and therapy.

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